Science and technology (S&T) must play a prominent and strategic role at all levels of United States foreign policy. On Day One, the Biden-Harris Administration should reinvigorate and reassert U.S. strength in science, technology, and data-driven decision making. S&T issues at the Department of State (Department) have historically been concentrated into specific offices and personnel, which has constrained the use of S&T as a tool to advance U.S. foreign policy goals. On Day One, the Administration can better identify, allocate, and elevate S&T issues and personnel throughout the Department. Building and rewarding diverse teams with the right mix of skills is good management for any organization, and could create significant progress toward breaking down the silos that prevent the realization of the full benefits of the S&T expertise that already exists among U.S diplomatic personnel.